支持细胞对精原干细胞增殖、分化调控的研究进展

doi:10.11843/j.issn.0366-6964.2019.02.003

摘要/Abstract

摘要：

哺乳动物精子发生是在睾丸支持细胞（Sertoli cells，SCs）调节下完成的，SCs不但为精子发生提供物理支撑和稳定微环境，而且通过分泌多种蛋白对生殖细胞发挥增殖、分化、凋亡、吞噬、免疫豁免等多种调节作用。生理状态下，SCs调控精子发生的确切机制还不是很清楚。因此，本文对SCs与精原干细胞（spermatogonial stem cells，SSCs）及系列生精细胞特殊的结构关系以及二者间的调控关系进行了综述，以期为推动二者间调控机理的深入研究及提高动物育种繁殖效率提供参考。

Abstract:

The spermatogenesis of mammals is regulated by Sertoli cells (SCs), which not only provide physical support and stable microenvironment to the spermatogenesis, but also regulate and control the proliferation, differentiation, apoptosis, phagocytosis and immune privilege of generative cells through the secretion of multiple proteins. However,the exact mechanism of SCs regulating spermatogenesis in physiological situations is unclear. Therefore, in this paper, the SCs and spermatogonial stem cells (SSCs) and a series of sperm cells special structure relationship and the regulation between the two were summarized, in order to promote the in-depth study of the regulatory mechanism between the two and to provide reference for improving the animal breeding efficiency.

中图分类号:

S814

王烁程, 陈晓丽, 张林波, 王栋. 支持细胞对精原干细胞增殖、分化调控的研究进展[J]. 畜牧兽医学报, 2019, 50(2): 253-260.

WANG Shuocheng, CHEN Xiaoli, ZHANG Linbo, WANG Dong. The Progress of the Study on the Regulation of the Proliferation, Differentiation of Spermatogonial Stem Cells by the Sertoli Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(2): 253-260.

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